In the last decade the approaches of the global history have been emphasized in order to visualize the progress, form and method which historians have undertaken when carrying out ambitious research projects to analyse and compare diverse geographical and cultural areas of Asia and Europe. But when dealing with comparisons and cross‐cultural studies in Europe and Asia, some scholarly works have exceeded of ambiguities when defining geographical units as well as chronology. In this project perceptions and dialogues between China and Europe are examined by analysing strategic geopolitical sites which fostered commerce, consumption and socioeconomic networks between China and Europe from 1680 to 1840 through a particular case study: Macau, connecting with South China, and Marseille in Mediterranean Europe.